KOZLOSKI et al. Short Title: MIR-181A REGULATES NF-ΚB SIGNALING IN DLBCL MIR-181A NEGATIVELY REGULATES NF-ΚB SIGNALING AND AFFECTS ACTIVATED B-CELL LIKE DIFFUSE LARGE B-CELL LYMPHOMA PATHOGENESIS
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190 words).
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miR-181a negatively regulates NF-κB signaling and affects activated B-cell-like diffuse large B-cell lymphoma pathogenesis.
Distinct subgroups of diffuse large B-cell lymphoma (DLBCL) genetically resemble specific mature B-cell populations that are blocked at different stages of the immune response in germinal centers (GCs). The activated B-cell (ABC)-like subgroup resembles post-GC plasmablasts undergoing constitutive survival signaling, yet knowledge of the mechanisms that negatively regulate this oncogenic signal...
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